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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12095 scientific papers returned from the database with the search filters currently being used below.

Adhesion-induced cortical flows pattern E-cadherin-mediated cell contacts

Authors:
Arslan FN, Hannezo É, Merrin J, Loose M, Heisenberg CP
Citation:
Curr Biol. 2024 Jan 8;34(1):171-182.e8. doi: 10.1016/j.cub.2023.11.067. Epub 2023 Dec 21
Epub:
Not Epub
Abstract:
Metazoan development relies on the formation and remodeling of cell-cell contacts. Dynamic reorganization of adhesion receptors...
Link:
https://www.sciencedirect.com/science/article/pii/S096098222301655X
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Arslan FN, Hannezo É, Merrin J, Loose M, Heisenberg CP. Adhesion-induced cortical flows pattern E-cadherin-mediated cell contacts. Curr Biol. 2024 Jan 8;34(1):171-182.e8. doi: 10.1016/j.cub.2023.11.067. Epub 2023 Dec 21.

amer1 Regulates Zebrafish Craniofacial Development by Interacting with the Wnt/β-Catenin Pathway

Authors:
Sun L, Ping L, Fan X, Fan Y, Zhang B, Chen X
Citation:
Int J Mol Sci. 2024;25(2):734. doi:10.3390/ijms25020734
Epub:
Not Epub
Abstract:
Microtia-atresia is a rare type of congenital craniofacial malformation causing severe damage to the appearance and hearing...
Link:
https://www.mdpi.com/1422-0067/25/2/734
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sun L, Ping L, Fan X, Fan Y, Zhang B, Chen X. amer1 Regulates Zebrafish Craniofacial Development by Interacting with the Wnt/β-Catenin Pathway. Int J Mol Sci. 2024;25(2):734. doi:10.3390/ijms25020734.

Variants in the WDR44 WD40-repeat domain cause a spectrum of ciliopathy by impairing ciliogenesis initiation

Authors:
Gerard A, Potocki L, Rosenfeld JA, Lalani SR, Scott TM, Scott D, Azamian MS, Louie R, Moore HW, Champaigne NL, Hollingsworth G, Torella A, Nigro V, Ploski R, Salpietro V, Zara F, Pizzi S, Chillemi G, Ognibene M, Cooney E, Do J, Linnemann A, Larsen MJ, Specht S, Walters KJ, Choi HJ, Choi M, Tartaglia M, Youkharibache P, Chae JH, Capra V, Park SG, Westlake CJ
Citation:
Nat Commun. 2024 Jan 8;15(1):365. doi: 10.1038/s41467-023-44611-2
Epub:
Not Epub
Abstract:
Accogli A, Shakya S, Yang T, Insinna C, Kim SY, Bell D, Butov KR, Severino M, Niceta M, Scala M, Lee HS, Yoo T, Stauffer J,...
Link:
https://www.nature.com/articles/s41467-023-44611-2
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gerard A, Potocki L, Rosenfeld JA, Lalani SR, Scott TM, Scott D, Azamian MS, Louie R, Moore HW, Champaigne NL, Hollingsworth G, Torella A, Nigro V, Ploski R, Salpietro V, Zara F, Pizzi S, Chillemi G, Ognibene M, Cooney E, Do J, Linnemann A, Larsen MJ, Specht S, Walters KJ, Choi HJ, Choi M, Tartaglia M, Youkharibache P, Chae JH, Capra V, Park SG, Westlake CJ. Variants in the WDR44 WD40-repeat domain cause a spectrum of ciliopathy by impairing ciliogenesis initiation. Nat Commun. 2024 Jan 8;15(1):365. doi: 10.1038/s41467-023-44611-2.

Antagonistic interactions safeguard mitotic propagation of genetic and epigenetic information in zebrafish

Authors:
Lawir DF, Soza-Ried C, Iwanami N, Siamishi I, Bylund GO, O Meara C, Sikora K, Kanzler B, Johansson E, Schorpp M, Cauchy P, Boehm T
Citation:
Commun Biol. 2024 Jan 5;7(1):31. doi: 10.1038/s42003-023-05692-3
Epub:
Not Epub
Abstract:
The stability of cellular phenotypes in developing organisms depends on error-free transmission of epigenetic and genetic...
Link:
https://www.nature.com/articles/s42003-023-05692-3
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lawir DF, Soza-Ried C, Iwanami N, Siamishi I, Bylund GO, O Meara C, Sikora K, Kanzler B, Johansson E, Schorpp M, Cauchy P, Boehm T. Antagonistic interactions safeguard mitotic propagation of genetic and epigenetic information in zebrafish. Commun Biol. 2024 Jan 5;7(1):31. doi: 10.1038/s42003-023-05692-3.

Macrophages inhibit extracellular hyphal growth of A. fumigatus through Rac2 GTPase signaling

Authors:
Tanner CD, Rosowski EE
Citation:
Infect Immun. 2024 Jan 3:e0038023. doi: 10.1128/iai.00380-23. Online ahead of print
Epub:
Not Epub
Abstract:
Macrophages act as a first line of defense against pathogens. Against Aspergillus fumigatus, a fungus with pathogenic potential...
Link:
https://journals.asm.org/doi/10.1128/iai.00380-23
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Tanner CD, Rosowski EE. Macrophages inhibit extracellular hyphal growth of A. fumigatus through Rac2 GTPase signaling. Infect Immun. 2024 Jan 3:e0038023. doi: 10.1128/iai.00380-23. Online ahead of print.

Piezo1-dependent regulation of pericyte proliferation by blood flow during brain vascular development

Authors:
Zi H, Peng X, Cao J, Xie T, Liu T, Li H, Bu J, Du J, Li J
Citation:
Cell Rep. 2024 Jan 3;43(1):113652. doi: 10.1016/j.celrep.2023.113652. Online ahead of print
Epub:
Not Epub
Abstract:
Blood flow is known to regulate cerebrovascular development through acting on vascular endothelial cells (ECs). As an...
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(23)01663-7
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zi H, Peng X, Cao J, Xie T, Liu T, Li H, Bu J, Du J, Li J. Piezo1-dependent regulation of pericyte proliferation by blood flow during brain vascular development. Cell Rep. 2024 Jan 3;43(1):113652. doi: 10.1016/j.celrep.2023.113652. Online ahead of print.

The RhoGEF Trio is transported by microtubules and affects microtubule stability in migrating neural crest cells

Authors:
Gossen S, Gerstner S, Borchers A
Citation:
Cells Dev. 2023 Dec 30;177:203899. doi: 10.1016/j.cdev.2023.203899. Online ahead of print
Epub:
Not Epub
Abstract:
Directed cell migration requires a local fine-tuning of Rho GTPase activity to control protrusion formation, cell-cell...
Link:
https://www.sciencedirect.com/science/article/pii/S266729012300075X
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Gossen S, Gerstner S, Borchers A. The RhoGEF Trio is transported by microtubules and affects microtubule stability in migrating neural crest cells. Cells Dev. 2023 Dec 30;177:203899. doi: 10.1016/j.cdev.2023.203899. Online ahead of print.

Histone lactylation couples cellular metabolism with developmental gene regulatory networks

Authors:
Merkuri F, Rothstein M, Simoes-Costa M
Citation:
Nat Commun. 2024 Jan 2;15(1):90. doi: 10.1038/s41467-023-44121-1
Epub:
Not Epub
Abstract:
Embryonic cells exhibit diverse metabolic states. Recent studies have demonstrated that metabolic reprogramming drives changes...
Link:
https://www.nature.com/articles/s41467-023-44121-1
Delivery Method:
electroporation
Organism or Cell Type:
Gallus gallus (chick)
Citation Extract:
Merkuri F, Rothstein M, Simoes-Costa M. Histone lactylation couples cellular metabolism with developmental gene regulatory networks. Nat Commun. 2024 Jan 2;15(1):90. doi: 10.1038/s41467-023-44121-1.

Development of FKBP5 ASOs to mitigate tau pathology

Authors:
Gebru NT, Hill SE, Blair LJ
Citation:
Alzheimers Dement. 2023;[Epub] doi:10.1002/alz.082780
Epub:
Not Epub
Abstract:
Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of abnormal...
Link:
https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.082780
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture: human neuroglioma, mouse hippocampal neuron, mice
Citation Extract:
Gebru NT, Hill SE, Blair LJ. Development of FKBP5 ASOs to mitigate tau pathology. Alzheimers Dement. 2023;[Epub] doi:10.1002/alz.082780.

AMONDYS 45 (Casimersen), a Novel Antisense Phosphorodiamidate Morpholino Oligomer: Clinical Considerations for Treatment in Duchenne Muscular Dystrophy.

Authors:
Vasterling ME, Maitski RJ, Davis BA, Barnes JE, Kelkar RA, Klapper RJ, Patel H, Ahmadzadeh S, Shekoohi S, Kaye AD, Varrassi G
Citation:
Cureus. 2023;15(12):e51237. doi:10.7759/cureus.51237
Epub:
Not Epub
Abstract:
AMONDYS 45 (casimersen) is an antisense oligonucleotide therapy used to treat Duchenne muscular dystrophy (DMD), a rare genetic...
Link:
https://www.cureus.com/articles/215610-amondys-45-casimersen-a-novel-antisense-phosphorodiamidate-morpholino-oligomer-clinical-considerations-for-treatment-in-duchenne-muscular-dystrophy#!/
Delivery Method:
intravenous (i.v.) infusion
Organism or Cell Type:
human
Citation Extract:
Vasterling ME, Maitski RJ, Davis BA, Barnes JE, Kelkar RA, Klapper RJ, Patel H, Ahmadzadeh S, Shekoohi S, Kaye AD, Varrassi G. AMONDYS 45 (Casimersen), a Novel Antisense Phosphorodiamidate Morpholino Oligomer: Clinical Considerations for Treatment in Duchenne Muscular Dystrophy.. Cureus. 2023;15(12):e51237. doi:10.7759/cureus.51237.

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